代表性论文:
1.Li R, Liu J, Ma J, Sun X, Wang Y, Yan J, Yu Q, Diao J, Yang C, Reid LM,Wang Y.*Fibrinogen improves liver function via promoting cell aggregation and fibronectin assembly in hepatic spheroids,Biomaterials.2022; 280, 121266. (IF=15.304)
2.Wang S, Wang X, Tan Z, Su Y, Liu J, Chang M, Yan F, Chen J, Chen T, Li C, Hu J,Wang Y.*Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury.Cell Research.2019.29, 1009–1026. (IF=46.297)
3.Yan F, Wang Y, Zhang W, Chang M, He Z, Xu J, Shang C, Chen T, Liu J, Wang X, Pei X,Wang Y.*Human embryonic stem cell–derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection.Hepatology. 2017; 66(3): 717-735. (IF=17.298)
4.Wang Y,*Qin J, Wang S, Zhang W, Duan J, Zhang J, Wang X, Yan F, Chang M, Liu X, Feng B, Liu J, Pei X. Conversion of human gastric epithelial cells to multipotent endodermal progenitors using defined small molecules.Cell Stem Cell. 2016; 19(4): 449-461. (IF=25.269)
5.Cardinale V,#Wang Y,#Carpino G, Mendel G, Alpini G, Gaudio E, Reid LM, Alvaro D. The biliary tree--a reservoir of multipotent stem cells.Nat Rev Gastroenterol Hepatol. 2012; 9(4): 231-240. (IF=73.082)
通讯作者/第一作者论文:
6.Wang, Q.;Liu, J.; Yin, W.;Sun, D.;Man, Z.; Jiang, S.; Ran, X.; Su, Y.;Wang, Y. *;Dong, J.Generation of Multicellular Tumor Spheroids with Micro-Well Array for AnticancerDrug Combination Screening Based on A Valuable Biomarker of Hepatocellular Carcinoma. Front. Bioeng. Biotechnol. 2022, 10.3389/fbioe.2022.1087656 (IF=6.064)
7.Sun, D.; Liu, J.;Wang, Y. *; Dong, J. Co-administration of MDR1 and BCRP or EGFR/PI3K inhibitors overcomes lenvatinib resistance in hepatocellular carcinoma. Frontiers in Oncology 2022, 10.3389/fonc.2022.944537.
8.Liu, J.; Li, R.; Zhang, T.; Xue, R.; Li, T.; Li, Z.; Zhuang, X.; Wang, Q.; Chen, Y.; Dong, J.; Zhang, Y.;Wang, Y. *High-Content Imaging of Human Hepatic Spheroids for Researching the Mechanism of Duloxetine-induced Hepatotoxicity. Cell Death & Disease 2022. s41419-022-05042-x
9.Liu, J.; Li, T.; Li, R.; Wang, J.; Li, P.; Niu, M.; Zhang, L.; Li, C.; Wang, T.; Xiao, X.; Wang, J.;Wang, Y. *Hepatic Organoid-based High Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines.Frontier in Pharmacology 2022, 13, 862830
10.Bai Z, Guo Z, Liu J, Chen YA, Lu Q, Zhang P, Hong L,Wang Y,*Dong J. Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. Front Oncol. 2022, 12: 860339.
11.Wang S, Wang X, Guo B, Su Y, Tan Z, Chang M, Diao J, Zhao Y,Wang Y.*Human primary epidermal organoids enable modeling of dermatophyte infections.Cell Death & Disease.2021, 12(1): 1-17.
12.Liu X, Qin J, Chang M, Wang S, Li Y, Pei X,Wang Y.* Enhanced Differentiation of Human Pluripotent Stem Cells into Pancreatic Endocrine Cells in 3D Culture by Inhibition of Focal Adhesion Kinase.Stem Cell Research & Therapy.2020.
13.Leng L, Ma J, Sun X, Guo B, Li F, Zhang W, Chang M, Diao J, Wang Y, Wang W,Wang Y.*Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development.Journal of tissue engineering.2020;11:2041731420972310.
14.Chang M, Liu J, Guo B, Fang X, Wang Y, Wang S, Liu X, Reid L,Wang Y.*Auto Micro Atomization Delivery of Human Epidermal Organoids Improves Therapeutic Effects for Skin Wound Healing.Front. Bioeng. Biotechnol.2020;doi: 10.3389/fbioe.2020.00110.
15.Diao J, Liu J, Wang S, Chang M, Wang X, Guo B, Yu Q, Yan F, Su Y,Wang Y.*Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration.Cell Death & Disease. 2019; 10(3): 238.
16.Liu J, Chen Z, Wang J, Li R, Li T, Chang M, Yan F,Wang Y.*Encapsulation of curcumin nanoparticles with MMP9-responsive and thermos-sensitive hydrogel improves diabetic wound healing.ACS applied materials & interfaces. 2018; 10(19): 16315-16326.
17.Wu Q, Liu J, Liu L, Chen Y, Wang J, Leng L, Yu Q, Duan Z,Wang Y.*Establishment of an ex vivo model of nonalcoholic fatty liver disease using a tissue-engineered liver.ACS Biomaterials Science & Engineering. 2018; 4(8): 3016-3026.
18.Liu J, Li R, Xue R, Li T, Leng L, Wang Y, Wang J, Ma J, Yan J, Yan F, Zhang Y,Wang Y.*Liver Extracellular Matrices Bioactivated Hepatic Spheroids as a Model System for Drug Hepatotoxicity Evaluations.Advanced Biosystems. 2018; 2(10): 1800110.
19.Pei H, Zhai C, Li H, Yan F, Qin J, Yuan H, Zhang R, Wang S, Zhang W, Chang M,Wang Y,*Pei X.* Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes.Stem cell research & therapy. 2017; 8(1): 252.
20.Wang Y, Chang L, Zhai J, Wu Q, Wang D,Wang Y.*Generation of carbamoyl phosphate synthetase 1 reporter cell lines for the assessment of ammonia metabolism.Journal of cellular and molecular medicine. 2017; 21(12): 3214-3223.
21.Qin J, Chang M, Wang S, Liu Z, Zhu W, Wang Y, Yan F, Li J, Zhang B, Dou G, Liu J, Pei X,Wang Y.*Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells.Scientific reports. 2016; 6: 37388.
22.Liu X, Yan F, Yao H, Chang M, Qin J, Li Y,Wang Y,*Pei X.* Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture.Cell and tissue research. 2014; 358(2): 359-369.
23.Wang Y,Lanzoni G, Carpino G, Cui CB, Dominguez‐Bendala J, Wauthier E, Cardinale V, Oikawa T, Pileggi A,Gerber D,Furth ME, Alvaro D, Gaudio E, Inverardi L, Reid LM. Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life‐long pancreatic organogenesis.Stem cells. 2013; 31(9): 1966-1979.
24.Liu X,#Wang Y,#Li Y, Pei X. Research status and prospect of stem cells in the treatment of diabetes mellitus.Science China Life Sciences. 2013; 56(4): 306-312.
25.Wang Y,Cui CB, Yamauchi M, Miguez P, Roach M, Malavarca R, Costello MJ, Cardinale V, Wauthier E, Barbier C, Gerber DA, Alvaro D, Reid LM. Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue‐specific biomatrix scaffolds.Hepatology. 2011; 53(1): 293-305.
26.Cardinale V,#Wang Y,#Carpino G, Cui CB, Gatto M, Rossi M, Berloco PB, Cantafora A, Wauthier E, Furth ME, Inverardi L, Dominguez-Bendala J, Ricordi C, Gerber D, Gaudio E, Alvaro D, Reid LM. Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets.Hepatology. 2011; 54(6): 2159-2172.
27.Zhou J, Zhao L, Qin L, Wang J, Jia Y, Yao H, Sang C, Hu Q, Shi S, Nan X, Yue W, Zhuang F, Yang C,Wang Y,*Pei X.* Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.PLoS One. 2010; 5(3): e9732.
28.Wang Y,Yao HL, Cui CB, Wauthier E, Barbier C, Costello MJ, Moss N, Yamauchi M, Sricholpech M, Gerber D, Loboa EG, Reid LM.Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates.Hepatology. 2010; 52(4): 1443-1454.
29.Wang M, Pei HL, Guan L, Zhang R, Jia Y, Li B, Yue W,Wang Y,*Pei X.* Hepatogenesis of adipose-derived stem cells on poly-lactide-co-glycolide scaffolds: in vitro and in vivo studies.Tissue Engineering Part C Methods. 2010; 16(5): 1041-1050.
30.Teng Y, #Wang Y,#Li S, Wang W, Gu R, Guo X, Nan X, Ma X, Pei X. Treatment of acute hepatic failure in mice by transplantation of mixed microencapsulation of rat hepatocytes and transgenic human fetal liver stromal cells.Tissue Engineering Part C Methods. 2010; 16(5): 1125-1134.
31.Zhou J, #Wang Y,#Yao H, He W, Chen H, Li S, Shi Y, Shi S, Nan X, Bai C, Liu B, Yue W, Mao N, Pei X. Differentiation Potential of Clonal HPP-CFC Into Hepatic Lineage in Developing Mouse Fetal Liver.Progress in Biochemistry and Biophysics. 2009; 36(7): 830-839.
32.Pei H, Yang Y, Xi J, Bai Z, Yue W, Nan X, Bai C,Wang Y,*Pei X.* Lineage restriction and differentiation of human embryonic stem cells into hepatic progenitors and zone 1 hepatocytes.Tissue Engineering Part C Methods. 2009; 15(1): 95-104.
33.Wang Y,Zhou J, Pei H, Teng Y, Wang M, Jia Y, Pei X. Potential of stem-cell-based therapies for liver regeneration.Cell Research. 2008; 18(S1): S11.
34.Wang Y,Nan X, Yu C, Li Y, Zhang R, Guan L, Yue W, Pei Y. Differentiation of bone marrow derived Thy-1+ beta2M-cells into liver cells in AA induced liver injury micro-environment.Zhonghua gan zang bing za zhi. 2005; 13(4): 274-277.
35.Wang Y,Nan X, Li Y, Zhang R, Yue W, Yan F, Pei X. Induction of umbilical cord blood-derived beta2m-c-Met+ cells into hepatocyte-like cells by coculture with CFSC/HGF cells.Liver Transpl. 2005; 11(5): 635-643.
36.Wang Y,Pei X. On the “plasticity” of adult stem cells and its application in regenerative medicine.Chinese Science Bulletin. 2003; 48(13): 1392-1396.