Faculty

Former positions:

1. Department of Neurology, Xuanwu Hospital, Capital Medical University

2. TJL & UTHSC, United States

Current positions:

1. Beijing Tsinghua Changgung Hospital

2. Tsinghua Medicine (Tsinghua-IDG/McGovern Institute for Brain Research at Tsinghua)

3. School of Clinical Medicine, Tsinghua University (Beijing Tsinghua Changgung Hospital)

4. Tsinghua University Hospital

Main Work:

① Pioneered super-selective intra-arterial thrombolysis for acute ischemic cerebrovascular disease in China; among the first institutions and individuals to implement the technique. In 1998, performed China’s first carotid artery stenting procedure for ischemic cerebrovascular disease, providing a novel treatment approach. Received the Clinical Technology Innovation Award from Xuanwu Hospital and the First Prize for Scientific and Technological Progress from the Beijing Health Bureau.

② Established innovative diagnostic and treatment paradigms for acute care and prevention of cerebrovascular disease. In 2008, founded China’s first “Endovascular Stroke Unit” at Xuanwu Hospital, integrating angiography, thrombolysis, stenting, bypass surgery, and carotid endarterectomy management. It was recognized as a pilot ward for quality services by the National Health Commission. Also initiated China’s first specialized outpatient clinics for stroke and stroke screening, promoting standardized procedures as a new model for specialized care. These models have been implemented in hospitals nationwide, significantly advancing stroke prevention and treatment.

③ Developed animal and cellular models of cerebral ischemia to explore mechanisms of ischemic brain injury and identify new therapeutic targets. Research has shown that downregulating CD151 modulates VCAM-1 expression and function in endothelial tetraspanin-enriched microdomains, inhibits neutrophil and monocyte infiltration, and alleviates neurological deficits post-ischemia, offering a potential new target for anti-adhesion molecule therapy in cerebral ischemia.

④ Advanced precision prediction and prevention of cerebrovascular disease. Led the establishment of the Northern Beijing Smart Stroke Prevention Network and proposed a foundational digital model for predicting cerebrovascular disease. The intelligent prevention and treatment model developed has been validated and applied in Tsinghua University communities and the northern Beijing region, benefiting millions and promoting precision monitoring and prevention of cerebrovascular disease.

1. Application of digital medicine and medical AI in neurological diseases

2. Research on new diagnostic and treatment technologies for cerebrovascular disease (including stem cells, materials, and image recognition)

3. Research on modern hospital and smart hospital management and standards

4. Research on etiology and pathogenesis of cerebrovascular disease

5. Neurobiological studies of cerebrovascular injury

6. Cognitive network research on vascular-related brain dysfunction

7. Research on community-based smart prevention and control systems for chronic diseases (including stroke)

(*Corresponding author, #Co-first author)

1. Chen W, Song X, Chen S, Chen Z, Fu M, Wei C, Zheng Z, Wu J, Li R. Variations of Arterial Compliance and Vascular Resistance due to Plaque or infarct in a Single Vascular Territory of Middle Cerebral Artery. Quantitative Imaging in Medicine and Surgery, 2023.

2. Chen W, Song X, Chen S, Wu J, et al. Blood flow and perfusion lateralization in border zone infarct using 4D flow and arterial spin labeling. Neuroradiology, 2022: 1-8.

3. Zhao X, Feng X, Li X, Wu J, et al. The G41D mutation in SOD1-related amyotrophic lateral sclerosis exhibits phenotypic heterogeneity among individuals: A case report and literature review. Medicine, 2022, 101(6).

4. Gao C, Jia W, Xu, Wu J, et al. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. Journal of Neuroinflammation, 2021, 18(1): 1-16.

5. Song X, Wei Q, Zhao X, Hou D, Zhao H, Wang L, Wu J. Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study. Journal of Atherosclerosis and Thrombosis, 2021.

6. Jia W, Wang Z, Gao C, Wu J, Wu Q. Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis. Cell Death & Disease, 2021, 12(4): 1-14.

7. Yang L, Wu J, Zhang J. A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation. Frontiers in Neurology, 2020, 11.

8. Song X, Zhao X, Liebeskind DS, Wu J, et al. Associations between systemic blood pressure parameters and intraplaque hemorrhage in symptomatic intracranial atherosclerosis: a high-resolution MRI-based study. Hypertension Research, 2020, 43(7).

9. Li J, Zhao L, Wang Z, Wu J, et al. Association of Serum Indirect Bilirubin Concentrations with Motor Subtypes of Parkinson's Disease. Neurodegenerative Diseases, 2020, 19(3-4): 1-7.

10. Xu W, Gao C, Wu J. CD151 Alleviates Early Blood–Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats. Cellular and Molecular Neurobiology, 2020.

11. Song X, Zhao X, Liebeskind DS, Wu J, et al. Incremental value of plaque enhancement in predicting stroke recurrence in symptomatic intracranial atherosclerosis. Neuroradiology, 2020.

Invention patents:

Method and system for constructing dynamic prediction models of cerebrovascular disease based on artificial intelligence (Patent No.: 202110924999.9)

Stroke disease prediction method and device based on artificial intelligence

Stroke risk screening device, electronic equipment, and storage medium

Microstate source localization method, device, electronic equipment, and storage medium

Software copyright:

Mobile intelligent stroke screening system

Outstanding Dedication Award, Stroke Prevention Committee, National Health Commission

Outstanding Contribution Award, National Health Commission

Top 10 Leading Talents in Public Health, Beijing

Golden Pen Award, Chinese Medical Journal

Team Leader, Dengfeng Talent Program

Top-tier Talent, “Ten-Hundred-Thousand” Talent Program, Beijing

First Prize, Beijing Municipal Science and Technology Progress Award

Vice Chair, Stroke Prevention and Control Expert Committee, National Health Commission

National Committee Member, Neurology Branch, Chinese Medical Association

National Committee Member, Neurology Physician Branch, Chinese Medical Doctor Association

Standing Member, Collateral Disease Branch, China Association of Traditional Chinese Medicine

Vice President, Young Physicians Branch, China Association of Chinese Medicine Research and Promotion

Vice Chair, Neurology Branch, Beijing Medical Association

Vice President, Beijing Stroke Prevention Association

Deputy Editor-in-Chief, Chinese Journal of Cerebrovascular Diseases

Editorial Board Member, International Journal of Stroke

Editorial Board Member, Stroke and Vascular Neurology

Editorial Board Member, Chinese Medical Journal

Editorial Board Member, Chinese Journal of Neurology

Editorial Board Member, Chinese Journal of Practical Internal Medicine