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Faculty

YANG Xuejun

Professor

Neurosurgery

Beijing Tsinghua Changgung Hospital

School of Clinical Medicine, Tsinghua University

yxja03728@btch.edu.cn

Education and Employment

2021.10—Present Tenure-Track Professor, Chief Physician, Director of the Department of Surgery, Chairman of Department of Neurosurgery, Beijing Tsinghua Chang Gung Hospital, Tsinghua University

2003.10—2021.10 Professor, Second-level Professor, Chief Physician, Master/PhD Supervisor, Deputy Director of Neurosurgery, and Director of Brain Tumor and Brain Function Ward, Tianjin Medical University General Hospital

2005.09-2005.09 Training at the University Medical Center of Utrecht, the Netherlands

2003.12—2006.1 Neurosurgical fellow, Visiting scientist, Mannheim Hospital, University of Heidelberg, Germany

2001.10-2002.01 Guest Lecturer, School of Medicine, Kurume University, Japan

1999.10—2003.9 Associate Professor, Tianjin Medical University General Hospital

1995.10—1999.9 Attending Physician, Tianjin Medical University General Hospital

1989.7—1995.9 Working as a resident physician in the Department of Neurosurgery, Tianjin Medical University General Hospital

1994.9—1997.7 PhD, Surgery (Neurosurgery), Tianjin Medical University

1991.9—1994.7 Master Degree, Surgery (Neurosurgery),Tianjin Medical University Surgery (Neurosurgery)

1984.9—1989.7 Bachelor Degree, Clinical Medicine, Tianjin Medical University

Research Field

pathogenesis and evolution of malignant glioma, tumor immune microenvironment and precision treatment

Brain function mapping, neurological function assessment and remodeling under pathophysiological state

Clinical transformation and application of digital and artificial intelligence technology in neurosurgical diseases

Selected Publications

1. Lin Y, Zhang K, Li S, Li S, Jin J, Jin F, Qin W, Hai L, Zhu M, Yu C, Liu Z, Yin T, Yang X. Relationship Between Perisylvian Essential Language Sites and Arcuate Fasciculus in the Left Hemisphere of Healthy Adults[J]. Neurosci Bull. 2017, 33(6):616-626.

2. Guo J, Zhang K, Zhang J, Zhao R, Liang Y, Lin Y, Yu S, Qin W, Yang X. Decoding Spatial Memory Retrieval in Cubical Space Using fMRI Signals[J]. Front Neural Circuits. 2021(15):624352.

3. Tao Z, Li T, Ma H, Yang Y, Zhang C, Hai L, Liu P, Yuan F, Li J, Yi L, Tong L, Wang Y, Xie Y, Ming H, Yu S, Yang X. Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation. Cell Death Dis. 2018 Oct 18;9(11):1063.

4.Tong L, Li J, Choi J, Pant A, Xia Y, Jackson C, Liu P, Yi L, Boussouf E, Lim M, Yang X. CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. Cancer Gene Ther. 2020 Sep;27(9):669-679.

5. Guo J, Fu X, Li Y, Ming H, Lin Y, Yu S, Wei H, Sun C, Zhang K, Yang X. Ultra high b-value diffusion weighted imaging enables better molecular grading stratification over histological grading in adult-type diffuse glioma. Eur J Radiol. 2023 Nov;168:111140.

6. Tong, Luqing; Li, Jiabo; Li, Qiuying; Wang, Xuya; Medikonda, Ravi; Zhao, Tianna; Li, Tao;Ma, Haiwen; Yi, Li; Liu, Peidong; Xie, Yang; Choi, John; Yu, Shengping; Lin, Yu; Dong, Jun; Huang , Qiang; Jin, Xun; Lim, Michael; Yang, Xuejun ; ACT001 reduces the expression of PD-L1 by inhibit ing the phosphorylation of STAT3 in glioblastoma, Theranostics, 2020, 10(13): 5943-5956

7. Hai, Long; Zhang, Chen; Li, Tao; Zhou, Xingchen; Liu, Bo; Li, Shuai; Zhu, Meng; Lin, Yu;Yu, Shengping; Zhang, Kai; Ren, Bingcheng; Ming, Haolang; Huang, Yubao; Chen, Lei; Zhao, Pengfei; Zhou, Hua; Jiang, Tao; Yang, Xuejun ; Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-kappa B(p65) pathway, Cell Death & Disease, 2018, 9(2): 0-158

8. Li Tao; Yi Li; Hai Long; Ma Haiwen; Tao Zhennan; Zhang Chen; Abeysekera Iruni Roshanie; Zhao Kai; Yang Yihan; Wang Wei; Liu Bo; Yu Shengping; Tong Luqing; Liu Peidong; Zhu Meng; Ren Bing cheng; Lin Yu; Zhang Kai; Cheng Cheng; Huang Yubao; Yang Xuejun ; The interactome and spatial red istribution feature of Ca2+ receptor protein calmodulin reveals a novel role in invadopodia-media ted invasion, Cell Death & Disease, 2018, 9(3): 0-292

9.Yi, Li; Zhou, Xingchen; Li, Tao; Liu, Peidong; Hai, Long; Tong, Luqing; Ma, Haiwen; Tao,Zhennan; Xie, Yang; Zhang, Chen; Yu, Shengping; Yang, Xuejun ; Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL 12/CXCR4, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38(1): 0-339

10.Tao Li, Farideh Mehraein-Ghomi, M Elizabeth Forbes, Sanjeev V Namjoshi, E Ashley Ballard, Qianqian Song, Ping-Chieh Chou, Xuya Wang, Brittany C Parker Kerrigan, Frederick F Lang, Glenn Lesser, Waldemar Debinski, Xuejun Yang, Wei Zhang,HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion. Molecular therapy. 2022 Apr 6;30(4):1610-1627.

Awards

2019, Co-author, ACC-SAP (Self-Assessment Program), American College of Cardiology

2019 – present, Member, Board of Trustees, Heart Rhythm Society (formerly NASPE)

Member Strategic Planning Task Force, Heart Rhythm Society (formerly NASPE)

2018 – 2019, Chair, Patient and Caregivers Committee, Heart Rhythm Society (formerly NASPE)

2018, Co-author, ACC-SAP (Self-Assessment Program), American College of Cardiology

2017-present, Leader, Destination Medical Community Workgroup, Mayo Clinic Rochester Workgroups Leader, Rochester Epidemiology Project, Department of Quantitative Health Sciences

1997 Third Prize for Science and Technology Progress of the Ministry of Health

1997 Second Prize for Science and Technology Progress of Tianjin

2003 Second Prize for Science and Technology Progress of Tianjin

2004 Tianjin Youth Science and Technology Award

2004 Tianjin "Tenth Five-Year Plan" Advanced Individual Honorary Title

2010 Tianjin "Science and Technology Communication Star"

2016 Wang Zhongcheng Chinese Neurosurgeon Academic Achievement Award

2019 China Brain Glioma Collaboration Group Outstanding Contribution Award

2022 "Power to Promote the Industry" Top Ten Medical Innovation Experts;

2022 "People's Famous Doctor-Outstanding Achievement" Honorary Title

2022 Seventh Annual Meeting of Medical Scientists "Top Ten Medical Elite Experts"

2022 Fifth People's Famous Doctor "Outstanding Achievement Award" Winner

Membership

President of the Neuro-Oncology Committee of the Chinese Anti-Cancer Association

Vice Chairman of the Glioma Committee of the Chinese Medical Association, former Chairman of the MDT Committee

Vice Chairman of the Neuro-Oncology Committee of the Western Returned Scholars Association

Vice Chairman of the Neuro-Oncology Committee of the Chinese Medical Association for the Promotion of Pharmaceutical Innovation

Member of the Neurosurgery Branch of the Chinese Medical Association

Standing Member of the Neurosurgery Branch of the Chinese Medical Equipment Society

Standing Member of the Neurosurgery Branch of the Chinese Medical Education Society

Standing Member of the Neurosurgery Branch of the Cross-Strait Medical Association

Leader of the Chinese Glioma Collaboration Group (4th term)

Chairman of the North China and Beijing-Tianjin-Hebei Glioma Diagnosis and Treatment Alliance

Chairman of the Neuro-Oncology Committee of the Beijing Oncology Society

Core Member of the Asian Society of Neuro-Oncology (ASNO)

Standing Member of the Sino-Japanese Neurosurgery Alliance

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