Faculty

CAO Pingping

Associate Professor

Otolaryngology-Head and Neck Surgery

Beijing Tsinghua Changgung Hospital

School of Clinical Medicine, Tsinghua University

cppa03283@btch.edu.cn

Education and Employment

2022.07-Present Tenure-Track Associate Professor, School of Clinical Medicine, Tsinghua University

2020.11-Present Associate chief surgeon, Otolaryngology-Head and Neck Surgery, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University

2018.04-2020.04 Visiting scholar, Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, USA

2011.07-2020.10 Associate chief surgeon, attending surgeon, Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

2005.09-2011.06 PhD. and MS., Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

2000.09-2005.06 B.S. Clinical Medicine, Xianning Medical College, Hubei

Research Field

The pathogenesis and clinical translation study on nasal polyps and chronic rhinosinusitis

The pathogenesis and clinical translation study on allergic rhinitis

Selected Publications

( # represents contributing equally, * represents corresponding author )

1. #Wang BF, #*Cao PP , Norton J, Poposki J, Klingler A, Suh L, et al. Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosunusitis with nasal polyps. J Allergy Clin Immunol.2023; 151:1379-90.

2. Wang B, Wang BF, Wang H, *Cao PP. Accidental finding of a buried foreign body in the occipital clivus of a child: a case report. Annals of Otolaryngology Head and Neck Surgery. 2023; 2:1-5.

3. *Cao PP, Wang BF, Norton JE, Suh LA, Carter RG, Stevens WW, Staudacher AG, Huang JH, Hulse KE, Peters AT, Grammer LC, Conley DB, Welch KC, Kern RC, Liu Z, Ye J, *Schleimer RP. Studies on activation and regulation of the coagulation cascade in chronic rhinosinusitis with nsal polyps. J Allergy Clin Immunol 2022; 150:467-76.

4. Cao PP, Wang Zhi-chao, Schleimer RP, Liu Z. Pathophysiologic mechanism of chronic rhinosinusitis and their roles in emerging disease endotypes. Ann Allergy Asthma Immunol 2019; 122:33-40.

5. #Jiang WX, #Cao PP, Li ZY, Zhai GT, Liao B, Lu X, Liu Z. A retrospective study of changes of histopathology of nasal polyps in adult Chinese in central China. Rhinology 2019; 57: 261-7.

6. Cao PP, Liao B, Liu Z. Promoting the study of chronic rhinosinusitis endotypes. Negative, 2018; 9(6):20-23.

7. #Wang BF, #Cao PP, Wang ZC, Li ZY, Wang ZZ, Ma J, Liao B, Deng YK, Long XB, Xu K, Wang H, Wang H, Zeng M, Lu X, Liu Z. Interferon-r-induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps. Allergy, 2017; 72:1384-97.

8. Cao PP, Shi LL, Xu K, Yao Y, Liu Z. Dendritic cells in inflammatory sinonasal disease. Clin Exp Allergy 2016; 46:894-906.

9. #Liao B, #Cao PP, Zeng M, Zhen Z, Wang H, Zhang YN, Hu CY, Ma J, Li ZY, Song J, Liu JX, Peng LY, Liu Y, Ning Q, Liu Z. Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps. Allergy 2015; 70:1169-80.

10. Cao PP, Liao B, Liu Z. Profiling the immunological characteristics of exacerbation of chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 2015; 45: 704-5.

11. Cao PP, Zhang YN, Liao B, Ma Jin, Wang BF, Wang H, Zeng M, Liu WH, Schleimer RP, Liu Z. Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 2014; 44: 690-700.

12. Cao PP, Long XB, Cui YH, Liu Z. Immunopathologic characteristics of chronic rhinosinusitis of Chinese and the significance. Chin J Otorhinolaryngol Head Neck Surg (China), 2014; 49: 786-9.

13. #Hu Y, #Cao PP, Liang GT, Cui YH, Liu Z. Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults. Laryngoscope 2012; 122: 498-503.

14. Cao PP,Li HB,Wang DY,Desrosiers M,Liu Z. Remodeling and inflammation in Chinese versus white patients with chronic rhinosinusitis Reply. Journal of Allergy and Clinical Immunology,2010,125(2):507-508.

15. Cao PP,Hua XY,Liu Z,Chu HQ,Cui YH. Mast cell and its relation to eosinophilic inflammation in CRSsNP. J Clin Otorhinolaryngol Head Neck Surg (China), 2010; 24:921-3.

16. Cao PP, Li HB, Wang BF, Wang SB, You XJ, Cui YH, Wang DY, Desrosiers M, Liu Z. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 2009; 124: 478-484.

17. Cao PP,Cui YH,Liu Z. Expression and significance of PD-L1 in laryngocarcinoma. J Clin Otorhinolaryngol Head Neck Surg (China), 2008; 22:1115-6.

18. Shi LL, Ma J, Deng YK, Chen CL, Wang H, Cao PP, Long XB, Zeng M, Liu Z. Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps. Allergy. 2021; 76:497-509.

19. Zeng M, Wang H, Liao B, Wang H, Long XB, Ma J, Liu JX, Cao PP, Ning Q, Liu Z. Comparison of efficacy of fluticasone propionate versus clarithromycin for postoperative treatment of different phenotype chronic rhinosinusitis: a randomized controlled trial. Rhinology 2019; 57:101-9.

20. Liao B, Liu JX, Li ZY, Zhen Z, Cao PP, Yao Y, Long XB, Wang H, Wang Y, Schleimer RP, Liu Z. Multimensional endotypes of chronic rhinosinusitis and their association with treatments outcomes. Allergy 2018; 73:1459-69.

21. Zhai GT, Wang H, Li JX, Cao PP, Jiang WX, Song J, Yao Y, Wang ZC, Wang ZZ, Wang MC, Liao B, Feng QM, Lu X, Wang H, Gao P, Liu Zheng. Immunoglobulin D-activated mast cells induce IgE synthesis in B cells in nasal polyps. J Allergy Clin Immunology 2018; 142:1489-99.

22. Song J, Wang H, Zhang YN, Cao PP, Liao B, Wang ZZ, Shi LL, Yao Y, Zhai GT, Wang ZC, Liu LM, Zeng M, Lu X, Wang H, Yang XP, Yu D, Bachert C, Liu Z. Ectopic lymphoid tissues support local immunoglobulin production in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2018; 141:927-37.

23. Liu Z,Cao PP. Difficult-to-treat chronic rhinosinusitis: current status and perspectives. J Clin Otorhinolaryngol Head Neck Surg (China),2016; 22:1747-9.

24. Zhang YN, Song J, Wang H, Zeng M, Zhai GT, Ma J, Li ZY, Liao B, Wang BF, Zhen Z, Wang N, Cao PP, Lin P, Ning Q, Liu Z. Nasal IL-4(+)CXCR5(+) T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps. J Allergy Clin Immunol 2016; 137:462-73.

25. Ma J, Shi LL, Deng YK, Wang H, Cao PP, Long XB, Zhang XH, Liu Y, Zeng M, Liu Z. CD8+ T cels with distinct cytokine producing features and low cytotoxic activity in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Clin Exp Allergy, 2016; 46:1162-75.

26. Wang BF, Cao PP, Long XB, Zhang XH, Xu K, Cui YH, Liu Z. Distinct mucosal immunopathologic profiles in atopic and nonatopic chronic rhinosinusitis without nasal polyps in Central China. Int Forum Allergy Rhinol, 2016; 6:1013-19.

27. Wang BF,Cao PP,Liu AG,Zeng M,Zhou LQ,Cui YH. Aneurysmal bone cyst of the mastoid bone: one case report. J Clin Otorhinolaryngol Head Neck Surg (China),2015;29:1312-4.

28. Weng JY,Zhen HT,Shi LL,Cao PP,Cui YH. Experience of Fusion image guided system in endonasal endoscopic surgery. J Clin Otorhinolaryngol Head Neck Surg (China),2015;29:1431-4.

29. Long XB,Cao PP,Wang N, Liu Y,Zhang XH. CC10 plasmid was constructed by using the TOPO TA Technology and expressed in BEAS-2B cells. Progress of Modern Biomedicine,2015;15:5801-5.

30. Zeng M, Li ZY, Ma J, Cao PP, Wang H, Cui YH, Liu Z. Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. BMC Immunol 2015; 16:37.

31. Rao LH, Li XD, Cao PP, Huang XW, Liu Z. Clinical analysis and literature review of primary melanoma in nasal cavity and sinus – report of 9 cases. J Clin Otorhinolaryngol Head Neck Surg (China), 2014; 28: 1162-4.

32. Zhen Z,Liao B,Li ZY,Cao PP,Liu Z. Factors influencing olfactory dysfunction in patients with chronic rhinosinusitis. J Clin Otorhinolaryngol Head Neck Surg (China), 2014;17:1282-4.

33. #Shi LL, #Song J, Xiong P, Cao PP, Liao B, Ma J, Zhang YN, Zeng M, Liu Y, Wang H, Cui YH, Huang SK, Liu Z. Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 2014; 190:628-38.

34. Huang XW,Wang CF,Cao PP,Cui WW,Can LJ,Cui YH. A contrastive analysis on the value of tympanograms and of temporal bone CT scans in diagnosis of secretory otitis media. Journal of Audiology and Speech Pathology, 2013; 21: 483-5.

35. Hu S,You XJ,Cao PP,Liu Z,Cui YH. The expression of NOD1 and NOD2 and the regulation of glucocorticoids on them in allergic rhinitis. J Clin Otorhinolaryngol Head Neck Surg (China), 2013; 27: 393-6.

36. #Shi LL, #Xiong P, Zhang L, Cao PP, Liao B, Lu X, Cui YH, Liu Z. Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns. Allergy 2013; 68:101-9.

37. #Zhang XH, #Zhang YN, Li HB, Hu CY, Wang N, Cao PP, Liao B, Lu X, Cui YH, Liu Z. Overexpression of miR-125b, a novel regulator of innate immunity, in eosniophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 2012; 185:140-51.

38. Zhang YN, Cao PP, Zhang XH, Lu X, Liu Z. Expression of microRNA machinery proteins in different types of chronic rhinosinusitis. Laryngoscope 2012; 122: 2621-7.

39. #Wang H, #Long XB, Cao PP, Wang N, Liu Y, Cui YH, Huang SK, Liu Z. Clara cell 10-KD protein suppresses chitinase 3-like 1 expression associated with eosinophilic chronic rhinosinusitis. Am J Respir Crit Care Med 2010; 181:908-16.

40. Long XB, Sun GB, Hu S, Liang GT, Wang N, Zhang XH, Cao PP, Zhen HT, Cui YH, Liu Z. Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. Oncol Rep 2009; 22:1189-95.

41. Long XB,Hu S,Cao PP,Liu Z,Zhen HT,Cui YH. The expression of oncogene c-myc and its role on human laryngeal cancer. J Clin Otorhinolaryngol Head Neck Surg (China), 2009; 23:1127-9.

42. Zhang F, Xiong ZG, Cao PP, You XJ, Gao QX, Cui YH, Liu Z. Lack of association of clara 10-kDa protein gene variant with chronic rhinosinusitis in a Chinese Han population. Am J Rhinol 2008; 22:376-80.

43. Wang H, Lu X, Cao PP, Chu Y, Long XB, Zhang XH, You XJ, Cui YH, Liu Z. Histological and immunological observations of bacterial and allergic chronic rhinosinusitis in the mouse. Am J Rhinol 2008; 22:343-8.

Awards and Membership

2020 Award of High-level Talent of Beijing City

2016 Award of “Top 10 excellent young scholar with Tongji Hospital”

2013 Award of the provincial outstanding Ph.D thesis with Hubei Province

2010 Award of outstanding Ph.D thesis with Huazhong University of Science and

Technology

2010 Award of “top 10 excellent publications for post-graduates” Tongji Medical College

2019- Membership of the American Association of Allergy, Asthma and Immunology

2019- Membership of the European Society of Rhinology

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