Faculty

1. Precise Intelligent Diagnosis of Biliary Diseases: High-Accuracy Computer Graphics-Based Intelligent Diagnostic Model for Bile Duct Dilation

   Achieved intelligent 3D visualization of the biliary tract through multi-scale network technology. Based on near-realistic 3D biliary images, mined morphological and geometric diagnostic markers for bile duct dilation that are difficult to describe by visual experience alone. Further developed a high-accuracy computer graphics-based intelligent diagnostic model using machine learning. This achievement can comprehensively and homogenously elevate disease diagnostic levels and efficiency while reducing misdiagnosis and mistreatment rates, holding significant importance for improving the diagnosis of complex benign biliary diseases.

2. Accurate Identification of Lesion Extent in Biliary Diseases: Research on Infiltration Range of Hilar Cholangiocarcinoma Using a Panoramic Digital Pathology System

   Established an innovative research system—the Panoramic Digital Pathology System—enabling visualizable and quantifiable pathological studies of large liver specimens. This system panoramically locates tumor infiltration ranges and displays pathological information such as overall differentiation degree and immune status, providing technical support for research on other hepatobiliary diseases.

   Using this system, clarified the intrahepatic infiltration range and pathways of hilar cholangiocarcinoma, providing high-level pathological evidence for exploring disease biology and selecting liver resection extent. Simultaneously identified liver resection margin status and established a standardized pathological evaluation method for margins. This series of studies provides high-level academic evidence for improving radical resection rates and enabling precise pathological evaluation.

3. Precision Surgical Planning for Hepatobiliary Diseases: Research on an Intelligent Precision Hepatobiliary Surgery Planning System

   Developed a precise, fully quantitative hepatobiliary surgery planning system based on deep learning and computer graphics technology. Capable of rapidly achieving high-precision intelligent 3D reconstruction of hepatic vasculature, liver segmentation, volume calculation, and sub-specialty hepatobiliary surgery planning. Significantly enhanced surgical planning efficiency and radical resection rates, while reducing planning workload and saving surgeons tens of thousands of hours in planning time.

4. Multi-Omics Studies on the Pathogenesis and Progression Mechanisms of Biliary Diseases

   The pathogenesis and progression mechanisms of biliary diseases are complex, involving interactions among genetic, environmental, metabolic, and immunological factors. Multi-omics research integrates data from genomics, transcriptomics, proteomics, metabolomics, and other levels, providing novel perspectives for deciphering the molecular mechanisms of biliary diseases, identifying potential biomarkers, and developing targeted therapies.

[1] Jin S*, Lin MY*, Xiang CH*, Liu ZP*, Wang SY, Jiang N, Li L, Shan SQ, Zeng JP, Yin HX, Zhang T, Yang CZ, Yang DL, Zhou H, Chen ZY, Dong JH&. The Status of Liver Margin in Perihilar Cholangiocarcinoma: A Multicenter Study. Ann Surg. 2024 Oct 21.

[2] Yang CZ, Zhu CZ, Chen ZY, Jiang N, and Zeng JP, Jin S&, Dong JH&, The Efficacy and Safety of Intrapancreatic Bile Duct Resection Applied in Type I of Congenital Bile Duct Dilation: A Multi-center Control Cohort Study, Ann Surg. 2025

[3] Jin S*, Jiang N*, Zhao JM, Xiao Y, Wang SY, Xiang CH, Lu Q, Shan SQ, Ruan HT, Yu SQ, Zeng JP, Yang SZ, Li L, Dong JH&. Pattern and extent of intrahepatic infiltration of perihilar cholangiocarcinoma - a case-control study based on liver panoramic digital pathology. Int J Surg. 2025 Jan 1;111(1):31-39.

[4] Dou J*, Jiang N*, Zeng J*, Wang S, Tian S, Shan S, Li Y, Xu Z, Lin X, Jin S&, Dong J&, Chen H&. Novel 3D morphological characteristics for congenital biliary dilatation diagnosis: a case-control study. Int J Surg. 2024 May 1;110(5):2614-2624.

[5] Wang B*, Jin S*, Yan Q, Xu H, Luo C, Wei L, Zhao W, Hou X, Ma W, Xu Z, Zheng Z, Sun W, Lan L, Zhang W, Mu X, Shi C, Wang Z, Lee J, Jin Z, Lin M, Jin H, Zhang L, Guo J, Zhao B, Ren Z, Wang S, Xu W, Wang X, Wang J, You Z&, Dong J&. AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system. Appl Soft Comput. 2021 Jan;98:106897.

[6] Zhang T*, Li L*, Yang DL, Jiang N*, Ge HJ, Lin MY, Yang CZ, Shan SQ, Sun H, Yan Z, Yuan XL, Sun K, Zeng JP, Xiang CH, Wang SY, Jin S&. Depth of Liver Invasion as a Novel Predictor for Outcome of Perihilar Cholangiocarcinoma. Am J Surg Pathol. 2025 May 22.

[7] Jiang N*, Wang SY*, Xiang CH, Yu SQ, Xiao Y, Zhou CY, Zeng JP, Jin S&. Patterns of Caudate Lobe Invasion of Hilar Cholangiocarcinoma: A Panoramic Histologic Study of Liver. Ann Surg Oncol. 2022 Oct;29(11):6804-6812.

[8] Zhang Y*, Li J*, Guan X*, Wang S, Jiang N, Jiao S, Liu Y, Zhang W, Hu H, Wang G, Liu H, Wang X, Bai W&, Zhou H&, Jin S&. Impact of lymph node metastasis on prognosis in colorectal cancer patients with liver metastasis and staging systems Refinement: An international multicenter retrospective cohort study. Eur J Surg Oncol. 2025 May 9;51(9):110124.

[9] Jin S*, Jiang N*, Shan SQ, Wang SY, Zhou CY, Yang SZ, Yuan XL, Xiang CH, Zeng JP, Dong JH&. Safety and benefit of modified mesohepatectomy in the treatment of bilobar involvement congenital biliary dilatation. World J Surg. 2024 Feb;48(2):446-455.

[10] Jiang N*, Xiang CH, Wang SY, Jin S&. ASO Author Reflections: Panoramic Histologic Patterns of Caudate Lobe Invasion in Hilar Cholangiocarcinoma. Ann Surg Oncol. 2022 Oct;29(11):6813-6814.

[11] Wang SY*, Jiang N, Zeng JP, Yu SQ, Xiao Y, Jin S&. Characteristic of Perineural Invasion in Hilar Cholangiocarcinoma Based on Whole-Mount Histologic Large Sections of Liver. Front Oncol. 2022 Mar 8;12:855615.

[12] Shang H*, Zeng JP*, Wang SY, Xiao Y, Yang JH, Yu SQ, Liu XC, Jiang N, Shi XL, Jin S&. Extrahepatic bile duct reconstruction in pigs with heterogenous animal-derived artificial bile ducts: A preliminary experience. World J Gastroenterol. 2020 Dec 14;26(46):7312-7324.

[13] Jin S*, Shi XJ, Wang SY, Zhang P, Lv GY, Du XH, Wang GY. Drainage fluid and serum amylase levels accurately predict development of postoperative pancreatic fistula. World J Gastroenterol. 2017 Sep 14;23(34):6357-6364.

[14] Wang SY*, Sun K*, Jin S*, Wang KY, Jiang N, Shan SQ, Lu Q, Lv GY&, Dong JH&. Predicting the outcomes of hepatocellular carcinoma downstaging with the use of clinical and radiomics features.

[15] Jin S*,, Shi XJ, Sun XD, Wang SY, Wang GY&. Sclerosing cholangitis secondary to bleomycin-iodinated embolization for liver hemangioma. World J Gastroenterol. 2014 Dec 14;20(46):17680-5.

[16] Jin S*, Shi XJ, Sun XD, Zhang P, Lv GY, Du XH, Wang SY, Wang GY&. The gastric/pancreatic amylase ratio predicts postoperative pancreatic fistula with high sensitivity and specificity. Medicine (Baltimore). 2015 Jan;94(3):e339.

[17] 金烁,项灿宏. 扩大左半肝切除联合肝中静脉切除重建治疗肝内胆管细胞癌[J]. 中华外科杂志,2019,57(1):48-49.

[18] 金烁, 石小举，王广义, 胰十二指肠切除术围手术期胰漏预测指标的研究进展, 中华肝胆外科杂志, 2014

[19] 金烁,石小举,孙晓东,等. 人工胆道的研究进展[J]. 中华肝胆外科杂志,2014,20(10):761-765.

[20] 欧霞,罗宇乐,刘智鹏,戴海粟,弓毅,吴英,江艳,白洁,金烁,陈志宇. 术前总胆红素对肝胆管结石病肝切除围手术期并发症的影响[J]. 中华消化外科杂志,2024,23(8):1087-1092.

• Published papers as first or corresponding author (including co-first/corresponding) in journals including Annals of Surgery, International Journal of Surgery, Applied Soft Computing, and American Journal of Surgical Pathology.

• Granted 4 patents as the first inventor.

• Completed one major transformation of patented scientific achievement as the primary contributor: the "Intelligent Precision Hepatobiliary Surgery Planning System" (Patent No. CN112446893B). The resulting product obtained NMPA Class II certification and has been deployed in 35 hospitals, significantly enhancing hepatobiliary surgical planning efficiency.

• Contributed to the publication of one monograph on hilar cholangiocarcinoma.

• Led the drafting of two industry guidelines for complex biliary diseases: "Guidelines for Diagnosis and Treatment of Intrahepatic Bile Duct Stones" and "Guidelines for Diagnosis and Treatment of Hilar Cholangiocarcinoma".

• Selected for provincial/ministerial-level high-level talent programs:

• Beijing Ninth Batch of Outstanding Young Talents

• Beijing Young Talent Lifting Project

• Beijing Physician-Scientist Program

• Received numerous awards, including:

• First Prize (Golden Finger Award), 3rd China General Surgery Young Surgeons' National Surgical Demonstration Finals & Chinese Surgery Golden Finger Award

• 2019 China Smart Health Medical Innovation Achievement Award

• First Prize, 4th National Clinical and Invention Competition

Sep 2022 - Present Hepatobiliary Youth Expert Working Group, Surgery Branch, Chinese Medical Doctor Association (CMDA) Member

Dec 2020 - Present Translational Medicine Branch, China Association of Medical Equipment (CAME) Member

Aug 2020 - Present Mobile Healthcare Working Committee, China Medicine Education Association (CMEA) Member

Jan 2022 - Dec 2022 Journal of Clinical and Translational Hepatology Associate Youth Editor

Jan 2022 - Dec 2023 Chinese Journal of General Surgery Youth Editorial Board Member